Přehled

Design and synthesis of dNTPs bearing different functional groups and polymerase synthesis of hypermodified DNA oligonucleotides containing 3-4 modified nucleotides. Automated SELEX for the selection of aptamers using a combination of modified nucleotides and selection of hypermodified aptamers against diverse targets (e.g. insulin and leptin) and application of the developed sensors for detecting biomarkers.

University:

Faculty of Science, Charles University

Group:

Michal Hocek Group, Bioorganic and Medicinal Chemistry of Nucleic Acids

Tutor:

Prof. Ing. Michal Hocek, Ph.D. DSc.

Field of study:

Organic chemistry

How to apply:

At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We offer exciting new projects in organic and medicinal chemistry, biochemistry, cell biology, molecular and structural biology, and analytical and physical chemistry.

• Online registration deadline: 3 March 2025
• Interview Day: 20 March 2025

Learn more and apply at www.uochb.cz/en/call-for-phd-applications.