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Description of the lab

Primary cilia are organelles with important functions in cellular signaling, morphogenesis and homeostasis. Mutations in genes that regulate cilia architecture or function result in disorders called ciliopathies. The ciliopathies comprise developmental syndromes, and also postnatal homeostatic disorders including cancer. In the research lab of Dr. Michaela Bosakova we focus on understanding the molecular mechanisms by which cilia are formed and used by protein kinases and signaling pathways (published work). Our ultimate goal is to comprehend the pathogenesis of selected ciliopathies, and contribute to development of their therapies.

The project and responsibilities

The selected applicant will lead a project that aims to target ciliary signaling in glioblastoma, which is one of the deadliest cancers with very limited treatment options. The approaches used in the project will comprise mainly establishment of primary cultures, CRISPR/Cas9 genome editing, cell and tissue imaging, and cell signaling experiments. Beyond the research tools and technology available in the lab and the hosting department, they will have access to the state-of-the-art instrumentation and services at the MUNI University campus core facilities. They will also participate in projects of other group members, including PhD and master students.

Qualifications:

  • PhD degree in the field of cell biology or similar
  • Significant, published experience with primary cilia research and/or cell signaling
  • Hands-on experience with CRISPR/Cas9 genome editing is a great advantage
  • Ability to work independently allied with a strong team spirit, scientific creativity, and motivation
  • Good communication in English

We offer:

  • Full-time, fully-funded position for 3 years (with a possibility of extension)
  • Gross monthly salary of 50,000-75,000 CZK (based on experience)
  • Possibility of scientific exchange at the collaborating labs at the University of Virginia, USA; the Cancer
  • Research Institute Oslo, Norway; and Sorbonne Université, France
  • International environment of the team and department
  • Access to excellent core facilities at the MUNI University campus
  • MED MUNI benefits (pension fund contribution, six weeks of vacation, meal allowance…)

Workplace: University campus, Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
Start of work: December 2024 or upon agreement
The deadline to apply is October 31, 2024

How to apply?

Please use the „E-Application“ link: Postdoc in The Biology of Primary Cilia Signaling at the Department of Biology, MED MUNI | Masaryk University
For more information about the position, contact Dr. Michaela Bosakova (bosakovam@med.muni.cz).

The applicant shall submit:

  • CV, including a full publication list and e-mail contacts of the PhD supervisor and one more referee
  • Motivation letter
  • PhD thesis (.pdf file)
  • PhD diploma (scan)

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