Přehled
We recently developed a method for synthesis of otherwise difficult-to-access atropisomers by nucleophilic aromatic substitution. One advantage is that starting materials, N‒H heterocycles and fluoroarenes, are readily available, and another is that the reactions are highly efficient and broadly applicable. However, the method currently produces racemates of atropisomers and is not catalytic. Accordingly, PhD students in our laboratory will develop catalytic atroposelective synthesis of such compounds and others. Several possibilities will be studied. The molecules synthesized in this project will be tested broadly in medicinal chemistry screenings.
University:
Faculty of Chemical Technology, UCT Prague; Faculty of Science, Charles University
Group:
Paulo Paioti Group, Catalytic Synthesis of Bioactive Molecules
Tutor:
Dr. Paulo Paioti
Field of study:
Organic chemistry
How to apply:
At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We offer exciting new projects in organic and medicinal chemistry, biochemistry, cell biology, molecular and structural biology, and analytical and physical chemistry.
- Online registration deadline: 3 March 2025
- Interview Day: 20 March 2025
Learn more and apply at www.uochb.cz/en/call-for-phd-applications.
