Přehled
The topic will be chemoenzymatic syntheses of tRNA containing modifications at specific positions. Methods of gradual elongation of RNA primers with modified nucleotides and exchange of DNA templates will be developed for introduction of modifications at specific position. The modified tRNAs will be studied in regulation of translation in collaboration with L. Valášek group (Inst. of Microbiology CAS).
University:
Faculty of Science, Charles University
Group:
Michal Hocek Group, Bioorganic and Medicinal Chemistry of Nucleic Acids
Tutor:
Prof. Ing. Michal Hocek, Ph.D. DSc.
Field of study:
Organic chemistry
How to apply:
At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We offer exciting new projects in organic and medicinal chemistry, biochemistry, cell biology, molecular and structural biology, and analytical and physical chemistry.
- Online registration deadline: 3 March 2025
- Interview Day: 20 March 2025
Learn more and apply at www.uochb.cz/en/call-for-phd-applications.
