Přehled
The PhD student will focus on the design and organic synthesis of new methyltransferase inhibitors, whether derived from viral, fungal, or human sources. In the course of developing these compounds, the candidate will employ in silico molecular modeling to streamline and accelerate the search and optimization of inhibitors. Nonetheless, the main emphasis of the project will remain on the organic synthesis of potential therapeutic agents.
Additionally, the project will include the preparation of ligand analogs equipped with suitable tags, whether fluorescent or functional (e.g., biotin for pull-down assays, thalidomide for PROTAC technology).
University:
Faculty of Chemical Technology & Faculty of Food and Biochemical Technology, UCT Prague; Faculty of Science, Charles University
Group:
Radim Nencka Group, Drug Design and Medicinal Chemistry
Tutor:
Mgr. Radim Nencka, Ph.D.
Field of study:
Organic chemistry, Drugs & Biomaterials
How to apply:
At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We offer exciting new projects in organic and medicinal chemistry, biochemistry, cell biology, molecular and structural biology, and analytical and physical chemistry.
- Online registration deadline: 3 March 2025
- Interview Day: 20 March 2025
Learn more and apply at www.uochb.cz/en/call-for-phd-applications.
