Overview

The Institute of Biotechnology of the Czech Academy of Sciences announces an open competition in accordance with the Act No. 283/1992 Coll. on the Czech Academy of Sciences, and the Statutes of the Czech Academy of Sciences for a position

PhD student in the Laboratory of Molecular Pathogenetics – a fully funded position in the field of Molecular and Developmental Biology

Understanding the different ways in which epigenetic signals and transcription factor networks govern self-renewal, cell specification, differentiation, and reprogramming is a key step for advances in cell-based therapy and perspectives for medicine. Using mouse models, we aim to investigate how elimination and miss-expression of selected transcription factors affect epigenetic landscapes and downstream targets during embryonic development, particularly pancreatic development. We will use Cre/loxP and global gene expression profiling (RNA sequencing), single cell sequencing, CUT&RUN chromatin profiling, FACS, confocal microscopy, immunohistochemistry, and in situ hybridization to evaluate molecular phenotypes and regulatory mechanisms.

Your qualifications and competences

  • The candidate should hold a master’s degree or an equivalent degree in cell biology, genetics, biomedicine, molecular biology or related sciences (as of December 2024)
  • The candidate must be willing to work with murine models
  • Good command of written and spoken English
  • Prior experience working with mice, microdissections, fluorescence microscopic methods, and knowledge of molecular methods and developmental biology and/or bioinformatics is a plus
  • Teamwork, enthusianism, and excellent communication skills

We offer to work in a creative, multidisciplinary international team. The laboratory is a part of the Institute of Biotechnology of the Czech Academy of Sciences (IBT, www.ibt.cas.cz) located at Centre BIOCEV, providing an inspiring multi-disciplinary research environment and access to state-of-the-art technologies and instruments. IBT/BIOCEV brings together > 500 scientists and students in > 50 research groups. Our laboratory collaborates with a number of European and US laboratories. We provide excellent training conditions for PhD students and competitive financial support,. She/he will enroll in a PhD program at Faculty of Science at the Charles University in Prague. The PhD application must be submitted by December 15, 2024.

If you have any further questions, please do not hesitate to contact Dr. Gabriela Pavlinkova by e-mail: gpavlinkova@ibt.cas.cz.

Publications to read:

  • Bohuslavova R, Fabriciova V, Smolik O, Laura Lebron-Mora, Abaffy P, Benesova S, Zucha D, Valihrach L, Berkova Z, Saudek F, Pavlinkova G*. NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development. Nature Communications 2023, 14 (1), 5554; https://doi.org/10.1038/s41467-023-41306-6
  • ISL1 controls pancreatic alpha cell fate and beta cell maturation. R Bohuslavova, V Fabriciova, L Lebron-Mora, J  Malfati, O Smolik, L Valihrach, S  Benesova, D  Zucha, Z Berkova, F Saudek, S  Evans, Gabriela Pavlinkova*. Cell & Bioscience 2023, 13, 53. https://doi.org/10.1186/s13578-023-01003-9 .

More details on the processing of personal data are available on the website: https://www.ibt.cas.cz/cs/o-ustavu/oficialni-dokumenty/gdpr/.

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