Přehled

Doctoral study program: Life Sciences (Faculty of Science, Masaryk University)

Supervisor:RNDr. Petr Tesina, Ph.D.

Annotation

Proteins are produced by ribosome-catalyzed translation of mRNAs in all domains of life. Translation is also critical in the context of human host-pathogen interaction where the ribosome, as the central molecular machine for genetic information expression, is the subject to numerous regulatory and quality control events and pathological interventions. The strategies adopted by viruses to reprogram translation and co-translational quality control machinery to promote infection are poorly understood. Thus, there is an urgent need for further research in this area to develop effective strategies for combating viral infections.

The successful candidate will study how viruses affect human translation and co-translational quality control with the aim of providing high-resolution structures of large macromolecular assemblies. He/she will utilize human cell cultures, protein expression and purification techniques and biochemistry methods to produce samples for cryogenic electron microscopy (cryo-EM). Comprehensive training in cryo-EM will be available to the successful candidate.

Funding of the PhD candidate:Národní institut virologie a bakteriologie (LX22NPO5103) – Ministerstvo školství, mládeže a tělovýchovy ČR / Národní plán obnovy

Requirements for candidate

The ideal candidate should have background in either molecular biology, biochemistry or structural biology. Experience with human cell culture work or protein biochemistry is a plus.

Information about the application process: https://www.ceitec.eu/ls-mm-phd/

Application webpage: https://www.ceitec.eu/translation-in-the-context-of-human-host-pathogen-interaction/t11440