Přehled

Design and synthesis of dNTPs bearing cycloalkyl or bicycloalkyl groups and their use in polymerase synthesis of modified DNA oligonucleotides containing the modified nucleotides. Then they will be used in SELEX with steroids as targets and the resulting aptamers will be evaluated using MST or BLI and applied in sensors for detecting steroid hormones and neurosteroids.

University:

Faculty of Science, Charles University

Group:

Michal Hocek Group, Bioorganic and Medicinal Chemistry of Nucleic Acids

Tutor:

Prof. Ing. Michal Hocek, Ph.D. DSc.

Field of study:

Organic chemistry

How to apply:

At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We offer exciting new projects in organic and medicinal chemistry, biochemistry, cell biology, molecular and structural biology, and analytical and physical chemistry.

• Online registration deadline: 3 March 2025
• Interview Day: 20 March 2025

Learn more and apply at www.uochb.cz/en/call-for-phd-applications.